Research articles
ScienceAsia 46 (2020):ID 457-461 |doi:
10.2306/scienceasia1513-1874.2020.059
Size-controlled chitosan nanoparticles prepared using
ionotropic gelation
Setia Budia,*, B. Asih Suliasihb, Indah Rahmawatia, Erdawatia
ABSTRACT: This work aimed at controlling the size of chitosan nanoparticles that were prepared by the ionotropic
gelation method. Quantities of chitosan and sodium tripolyphosphate (STPP) were optimized to obtain a fine size and
narrow size distribution of the nanoparticles. X-ray diffraction and selected area electron diffraction patterns indicated
the existence of both crystalline and amorphous phases of chitosan. Particle size and size distribution were determined
using transmission electron microscopy and dynamic laser scattering techniques. The size of the chitosan particles
decreased with a reduction in STPP content due to a decrease in cross-link bonding and the formation of aggregate
particles. Using this facile approach, the finest particles of chitosan were obtained in a range of 3?6 nm.
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| a |
Department of Chemistry, Faculty of Mathematics and Science, Universitas Negeri Jakarta,
Jakarta Timur 13220 Indonesia |
| b |
Faculty of Pharmacy, Universitas Indonesia, Depok 16424 Indonesia |
* Corresponding author, E-mail: setiabudi@unj.ac.id
Received 9 Jul 2019, Accepted 25 Jul 2020
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