Research articles
ScienceAsia 49 (2023):ID 627-634 |doi:
10.2306/scienceasia1513-1874.2023.060
Carbon quantum dots as drug carriers for tumor-associated
macrophage repolarization following photothermal therapy
Haizhong Yuana,?, Hui Yangb,?, Pin Yuanc, Tingting Wangd, Quan Zhouc,*
ABSTRACT: With the development of nanotechnology in the anticancer application, photothermal therapy (PTT) based
on nanoparticles (NPs) could repolarize the tumor-associated macrophages (TAMs) from protumor (M2) phenotype
to antitumor (M1) phenotype, thus regulating the tumor-suppressive immune environment. However, the inevitable
local inflammation occurred in the residual tumor microenvironment after PTT recruited abundant abnormal TAMs
to induce immune escape and survival of the remaining tumor cells. Here, TMP195 loaded carbon quantum dots
(CQDs@TMP195) were developed as innovative nanoplatforms to achieve promising PTT and immune responses.
In the nanoplatforms, CQDs with distinct antitumor performance were applied as an ideal drug-loading nanocarrier
and initiated photothermal effects to generate heat under near-infrared (NIR) irradiation. The loaded TMP195 could
repolarize the M2 phenotype TAMs into the M1 phenotype TAMs. Based on our work, the in vitro antitumor effects
implied that CQDs@TMP195 could significantly kill cancer cells with minimal toxicity to normal cells. This study
proposes a feasible therapeutic strategy for polarizing TAMs to the immunocompetent M1 phenotype after PTT.
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| a |
Pharmacy Department of PKU Care Lu?an Hospital, Shanxi 046204 China
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| b |
Department of Public Health and Preventive Medicine, Changzhi Medical College, Shanxi 046000 China |
| c |
Nanjing Jiatong Micro-nano Technology Co., Ltd., Jiangsu 210000 China |
| d |
Nanjing Seth Technology Service Co., Ltd., Jiangsu 210043 China |
* Corresponding author, E-mail: 2262691619@qq.com
Received 25 Nov 2022, Accepted 23 May 2023
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