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Research Article

ScienceAsia 26 (2000) : 015-020 |doi: 10.2306/scienceasia1513-1874.2000.26.015


25-Deoxyecdysteroids: Synthesis and
Moulting Hormone Activity of
Two C-25 Epimers of Inokosterone

Boon-ek Yingyongnarongkul and Apichart Suksamrarn*

ABSTRACT: A convenient synthesis of inokosterone, pterosterone and 24-epi-pterosterone has been accomplished. The former ecdysteroid exists as two C-25 epimers and could be separated from each other through their diacetonide derivatives. Each of the C-25 epimers has been subjected to moulting hormone activity testing using the Musca bioassay and it was found that the less polar isomer, inokosterone "epimer 1”, was approximately two-fold more active than the more polar component, inokosterone "epimer 2"

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Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240,

* Corresponding author.

Received 27 Dec 1999, Accepted 2 Feb 2000