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Research Article

ScienceAsia 18 (1992): 027-040 |doi: 10.2306/scienceasia1513-1874.1992.18.027

 

EFFECT OF SOLVENT STRENGTH ON THE CHROMATOGRAPHIC BEHAVIOR OF DRUGS IN REVERSED-PHASE HPLC

 

SURAPOTE WONGYAI

ABSTRACT: The water content of the injected sample significantly influenced the chromatographic behavior of acidic, neutral and basic drugs on reversed-phase columns. The number of theoretical plates of each compound distinctly depends on the water concentration. Resolution of previously unresolved peaks could be achieved without change in retention. Application of this method to different medicament formulations are given.

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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rangsit University, Phathum Thani 12000, Thailand.

Received April 20, 1992