ScienceAsia 14 (1988): 137-140 |doi: 10.2306/scienceasia1513-1874.1988.14.137

THE INTERACTION OF H⁺ AND Zn (II) WITH GUANOSINE

K. KRIAUSAKUL-INDARATNA,^a P. DOUNGDEE^b AND B.M. RODE^a,b

ABSTRACT: Protonation and complex formation of guanosine with Zn(II) in aqueous solution have been investigated by means of potentiometry. Under biological conditions (pH ~ 7, 37 ^oC) the dominant species are the neutral LH molecule and the zinc complex ZnLH²⁺, with logarithmic stability constants of 2.12 0.01, and 1.20 0.01, respectively. These results are in accord with the previous experimental findings of nucleoside base-Zn(II) interactions in DNA.

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a) Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10500, Thailand.
b) Institut fur Anorganische und Analytische Chemie, University of Innsbruck, A-6020 Innsbruck, Innrain 52 a, Austria.

Received 20 March 1987