ScienceAsia 14 (1988): 051-059 |doi: 10.2306/scienceasia1513-1874.1988.14.051

OVICIDAL ACTIVITY OF 6-SUBSTITUTED-2- AND -4-AMINOQUINOLINES AND THEIR MONO AND BIS (THIOUREA) DERIVATIVES AGAINST HUMAN HOOKWORM

OPA VAJRAGUPTA,^a SOMCHAI PANANOOKOOLN,^b PITTAYA TUNTIWACHWUTTIKUL^c AND WILLIAM O. FOYE^d

ABSTRACT: A series of 6-methoxy- and 6-methyl-2- and -4- quinolyl mono and bis thioureas was synthesized as potential anthelmintic agents against human hookworm. Tests for ovicidal activity against Necator americanus isolated from human patients showed the 6-methoxy-2- and -4-quinolyl mono thioure.as to cause better than 90 % ovicidal effects, and the 6-substituted-2- and 4-aminoquinolines to give 100 % inhibition of egg survival. This publication therefore reports a new type of agents with activity against human hookworm.

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a Faculty of Pharmacy, Mahidol University, Bangkok, Thailand,
b Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand,
c Department of Medical Science, Ministry of Public Health, Bangkok, Thailand,
and d Massachusetts College of Pharmacy and Allied Health Sciences, Boston, Ma 02115

Received 14 August 1987