 BackShort Report ScienceAsia 13 (1987): 113-117 |doi: 10.2306/scienceasia1513-1874.1987.13.113
THE EFFECT OF MEGADOSAGE VITAMIN E CONSUMPDON ON RAT THYMOCYTE ROSETTE-FORMING CELLS AND PROLIFERATIVE RESPONSE
PREECHA SULAIMANEE AND MOLVIBHA VONGSAKULABSTRACT: Cell-mediated immunity was studied in Wistar rats following treatment for 28 consecutive days with megadose quantities (560, 1120 and 2240 mg/kg) of vitamin E. The numbers of thymocyte rosette-forming cells were significantly increased (p < 0.05) only in the two groups of treated rats (560 and 1120 mg/kg). The proliferative response of thymocytes to phytohemagglutinin-P of all.groups of treated rats were reduced compared to controls, but were not different between the vitamin E-supplemented groups. Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand Received 9 January 1987
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