ScienceAsia 11 (1985): 189-195 |doi: 10.2306/scienceasia1513-1874.1985.11.189

THE EFFECT OF CAPSAICIN ON FLUID AND ELECTROLYTE TRANSPORT IN RAT ILEUM

WATCHARAT LIMRATANA,^a BOONTIUM KONGSAKTRAKOON^a and KAJIT RUNGSRISAWAD^b

ABSTRACT: The effect of capsaicin on intestinal net fluid and electrolyte transport was studied in the ileum of anaesthetized rats. The loop of the mid ileum was instilled with fluid in two consecutive 30-min periods. The control group was instilled with saline-bicarbonate solution in both periods. The three test groups were instilled with saline-bicarbonate solution containing capsaicin at concentrations of 0.14 or 0.21 or 0.28 mg/ml in the first period and instilled with saline-bicarbonate solution in the second period. The net transport of fluid, Na⁺, Cl^- and HCO₃^- of each tested group was compared with that of the control. The results of this study indicate that capsaicin can cause an augmentation in net fluid, Na⁺ and HCO₃^- absorption while it has no effect on net Cl^- transport.

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a. Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
b. Department of Clinical Chemistry, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.

Received 11 July 1985