ScienceAsia 11 (1985): 177-181 |doi: 10.2306/scienceasia1513-1874.1985.11.177

MUTAGENIC AND ANTIBACTERIAL ACTIVITY TESTING OF NIMBOLIDE AND NIMBIC ACID

W. ROJANAPO¹, S. SUWANNO², R. SOMJAREE², T. GLINSUKON³ AND Y. THEBTARANONT⁴

ABSTRACT: No mutagenicity of nimbolide and nimbic acid was detected by Ames'test using both TA98 and TA100 tester strains. However, nimbolide(O.875 mg/disk) did exhibit antibacterial activity (3 117 strains) against S. aureus, S. coagulase (+) and S. coagulase (-) whereas nimbic acid (3.5 mg/disk) exhibited this activity (5/17 strains) against S. aureus, B. subtilis, S. coagulase (+), S. coagulase (-) and Diphtheroidae.

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Research Division¹, National Cancer Institute and Departments of Physiology^2,3 and Chemistry⁴, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

Received 4 October 1985