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Short Report
ScienceAsia 8 (1982): 215-223 |doi: 10.2306/scienceasia1513-1874.1982.08.215
ACYLATION OF 2-ARYL-2-DIMETHYLAMINOACETONITRILES.
SIMPLE SYNTHESES OF UNSYMMETRICAL -DICARBONYL COMPOUNDS AND -KETOESTERS
VICHAI REUTRAKULa, SURACHAI NIMGIRAWATH,b VICHUKORN PRAPANSIRIa and YUPAYAO SRIKIRINa
ABSTRACT: Reactions of 2-lithio anions derived from 2-aryl-2-dimethylaminoacetonitriles with acyl halides or ethyl chloroformate followed by hydrolysis with copper (II) sulfate in 95% ethanol provide convenient syntheses of various unsymmetrical -diketones and
-ketoesters, respectively.
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a Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road,
Bangkok 10400, Thailand.
b Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand.
Received 4 June 1982
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