ScienceAsia 6 (1980): 183-190 |doi: 10.2306/scienceasia1513-1874.1980.06.183

INDUCTION OF DECIDUALIZATION IN PSEUDOPREGNANT HAMSTERS BY INTRAPERITONEAL INJECTION OF PROSTAGLANDIN F_2a AND HISTAMINE RELEASER (PYRATHIAZINE HYDROCHLORIDE)

PUTTIPONGSE VARAVUDHI and CHATSUDA NA POMBHET

Summary: It is possible to induce decidua/ization in pseudopregnant hamsters without operation and manipulation of uterine tissues by intraperitioneal injection of 2-3x 50 micrograms of PGF_2a or 20 mg of a histamine releaser (pyrathiazine hydrochloride) during 9.00 and /5.00 h of day 4 (D₄) of pseudopregnancy. Autopsy on D₉ showed maximal decidual induction score (DISj.and significant uterine and endometrium weight increments. Unlike PGF_2a, PGE₂ did not induce this response. Indomethacin injection of 03-4.0 mg, either given as a single or multiple doses, was unable to effect complete inhibition of decidual cell reaction induced by uterine traumatization. Our evidence is in lavor of the contention that both PGF_2a and histamine and neither alone may mediate the process of initiation and decidual formation in hamster.

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Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand

Received 2 July 1980