ScienceAsia 6 (1980): 081-089 |doi: 10.2306/scienceasia1513-1874.1980.06.081

THE ALKALOIDS OF HOLARRHENA CURTISII KING AND GAMBLE

JACK R. CANNON, EMIL L. GHISALBERTI and VITCHU LOJANAPIWATNA^a

Summary: The leaves of a Thai form of Holarrhena curtisii King and Gamble have yielded the aminoglycosteroid holacurtine (2) and a new base which has been formulated as N-demethylholacurtine (4). The n.m.r. spectrum of N-acetylholacurtine (3) shows evidence of restricted rotation about the amide linkage but this feature is absent from the spectrum of N-acetyl-N-demethylholacurtine (5).

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Department of Organic Chemistry, University of Western Australia, Nedlands, W.A. 6009, Australia
a present Address: Department of Chemistry, Faculty of Science, Prince of Songkla University, Haad-Yai, Songkla, Thailand.

Received 22 November 1979