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Short Report

ScienceAsia 4 (1978): 188-192 |doi: 10.2306/scienceasia1513-1874.1978.04.188

 

TOXICITY OF CYTOCHALASINE IN FEMALE RATS

 

A. SUVANNAPURA and T. GLINSUKON

Summary: Intraperitoneal adminisrration of cytochalasin E causes a dose-dependent relation. ship on the extravascular effusion of plasma into peritoneal cavity of female rats. Lethal dose of cytochalasin E (3.50 mg/kg) had a pronounced effect on a sharp decrease in plasma volume to 38.0 % and the simultaneous accumulation of about 3.00 ml of peritoneal fluid within 1 h after treatment. The cause of death appears to be due to a plasma hypovolumic shock.

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Department of Physiology. Faculty of Science, Mahidol University, Bangkok 4. Thailand

Received 26 September 1978