Research articles
ScienceAsia 52 (2023): 1-9 |doi:
10.2306/scienceasia1513-1874.2023.017
Concomitant increased brain-derived neurotrophic factor
and interleukin-6 protein expression with postnatal exercise
associated spatial memory preservation in prenatal-stressed
rat offspring
Pornprom Surakula, Rapeepun Vanichviriyakitb, Rujapope Sutiwisesakc, Sukonthar Ngampramuand,*
ABSTRACT: Any perturbation to the neurohormonal-immune system during the fetal developmental period carries
over effects later in life. Prenatal stress (PS) induces hippocampal changes in the structure and functions that could
lead to cognitive impairment and psychiatric disorders. Increasing evidence indicates that physical exercise could
ameliorate cognitive impairment in both young and old rats. We investigated the therapeutic effect of the postnatal
voluntary wheel running (VWR) exercise on cognitive impairment that developed from prenatal maternal restraint
stress. The restraint stress was carried out during gestation day (GD)14?21 in the pregnant Sprague-Dawley rats. VWR
was performed in the rat pups on postnatal day (P)25?40. After that, spatial memory performance was tested with
the Morris water maze (MWM) during P36?40. The effect of prenatal stress and the potential effects of the VWR
on the levels of hippocampal synaptic proteins, brain-derived neurotrophic factor (BDNF), and interleukin (IL)-6 in
the rat offspring were ascertained with Western blot analysis. Stress during the prenatal period induced decreases in
synaptic proteins and BDNF, but an increase in IL-6. Postnatal exercise ameliorated the adverse effects of PS on protein
expression. The MWM test confirmed the ameliorative effect of VWR on spatial memory performance of the pups. Our
f
indings suggest that postnatal exercise has a high potential to ameliorate the adverse effects of maternal stress and
return healthy neuroendocrine-immune system and spatial memory to rat offspring.
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| a |
Faculty of Allied Health Sciences, Burapha University, Chonburi 20131 Thailand |
| b |
Anatomy Department, and Center of Excellence for Shrimp Molecular Biology and Biotechnology, Faculty of
Sciences, Mahidol University, Bangkok 10400 Thailand |
| c |
Department of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700 Thailand |
| d |
Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhornpathom 73170
Thailand |
* Corresponding author, E-mail: sukonthar.nga@mahidol.ac.th
Received 6 Jul 2024, Accepted 0 0000
|
