Research articles
ScienceAsia 50 (2024):ID 2024065 1-8 |doi:
10.2306/scienceasia1513-1874.2024.065
Protective effects of functional powdered beverage containing
Cassumunar ginger (Zingiber cassumunar Roxb.), soybean
(Glycine max), and cinnamon (Cinnamomum burmannii)
against hyperlipidemia and injuries of liver and kidney in
high-fat-diet rats
Nurkhasanah Mahfudha,*, Ika Dyah Kumalasarib, Nanik Sulistyania, Candra Azzahraa, Salma Dewina Salimaha, Suryati Suryatia, Zainul Amiruddin Zakariac
ABSTRACT: A high-fat consumption can cause hyperlipidemia, which is marked by an increase of total cholesterol,
triglycerides, and low-density lipoprotein (LDL); and a decrease of high-density lipoprotein (HDL) in serum. This
condition can lead to various degenerative diseases. This study aimed to observe the effects of functional powdered
beverage (FPB) on levels of cholesterol, triglyceride, blood urea nitrogen (BUN), and creatinine; SGOT and SGPT
activities; and liver histopathology in rats given a high-fat diet (HFD). The FPB was made of Zingiber cassumunar
rhizome, soybean, and cinnamon. Test animals were divided into six groups: normal, negative control, positive control,
and three treatment groups. While the normal group was received only a standard diet, the other five groups were
received HFD along the studies. In addition, the three treatment groups were treated with different doses of FPB of
1000, 1500, and 2000 mg/kg BW, respectively. Biochemical parameters were measured with UV-Vis spectrophotometry,
and histopathological observations used hematoxylin and eosin (H&E) staining. The data were analyzed statistically
at a 95% confidence level using SPSS. In comparison to the negative control, the results demonstrated a statistical
reduction in cholesterol, triglycerides, BUN, and creatinine levels (p < 0.05), indicating the effect of the functional
powdered beverage as an antihyperlipidemic agent and protection for hyperlipidemia-associated kidney injuries. SGOT
and SGPT activities were also lowered significantly (p < 0.05) in comparison to the negative control, suggesting a
hepatoprotective effect of the beverage in HFD. Improved liver histology and decreased hepatosomatic index (HI) in
the three treatment groups attested to the beverage?s hepatoprotective activity, with the best pharmacological effects
obtained at 2000 mg/kg BW.
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a |
Faculty of Pharmacy, Universitas Ahmad Dahlan, Janturan, Yogyakarta 55164 Indonesia |
b |
Faculty of Industrial Engineering, Universitas Ahmad Dahlan, Bantul, Yogyakarta 55166 Indonesia |
c |
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah,
Kota Kinabalu, Sabah 88400 Malaysia |
* Corresponding author, E-mail: nurkhasanah@pharm.uad.ac.id
Received 17 Jan 2023, Accepted 18 Apr 2024
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