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Short reports

ScienceAsia 35 (2009): 306-309 |doi: 10.2306/scienceasia1513-1874.2009.35.306


Effects of solvent properties on the Soxhlet extraction of diterpenoid lactones from Andrographis paniculata leaves


Andri Cahyo Kumoroa,*, Masitah Hasana,b, Harcharan Singha,c

 
ABSTRACT:     A solid-liquid extraction was performed for the leaves of Andrographis paniculata in order to obtain two bioactive components, andrographolide and deoxyandrographolide. The problem of hydrolysable components and solvent removal difficulties in the conventional extraction led us to study further the effects of solvent properties on the conventional extraction using Soxhlet method in order to determine the best solvent or solvent mixture for high extraction yield of A. paniculata. This solvent selection is very important prior to alternative extraction methods since it can be used as a pre-extraction solvent, main solvent, or co-solvent. Based on the yield of extract and andrographolide and deoxyandrographolide content, methanol was found to be the best solvent.

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a Department of Chemical Engineering, Faculty of Engineering, Diponegoro University, Jl. Prof. Soedarto, SH Tembalang Semarang, Indonesia
b Department of Chemical Engineering, Faculty of Engineering, University of Malaya Lembah Pantai, Kuala Lumpur 50603 Malaysia
c Mewah Oil Sdn Bhd, Lot 40, Section 4, Fasa 2A, Pulau Indah Industrial Park, Jalan Sungai Pinang 5/1, Pulau Indah, 42920 Pulau Indah, Selangor Darul Ehsan, Malaysia

* Corresponding author, E-mail: c.k.andrew@undip.ac.id

Received 11 Sep 2008, Accepted 2 Jun 2009